Proteome Profiling of Human Cutaneous Leishmaniasis Lesion

Proteome Profiling of Human Cutaneous Leishmaniasis Lesion

In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network an...

Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion

Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found in all patient lesions at the time of biopsy, the patients could be stratified...

Cutaneous leishmaniasis and human conflict.

Cutaneous Manifestations of Human and Murine Leishmaniasis

The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a c...

Correction: Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion

[This corrects the article DOI: 10.1371/journal.pntd.0004992.].